In this paper we present a seismic-stratigraphic interpretation of the Mesozoic and Tertiary geologic history of the Flemish Pass Basin, offshore Newfoundland, based on seismic data and data from seven wells that were integrated on the BP subsurface integrated interpretation system (SIIS). Four megasequences are identified. Megasequence 1 (MS1) is Triassic to lower Berriasian, and includes poorly known sediments associated with Triassic-Early Jurassic rifting prior to spreading between the North African and American continents. The uppermost mappable unconformity-bounded unit within MS1 contains major Kimmeridgian to Portlandian marine source rocks deposited in two east-west-trending subbasins in the Baccalieu and Gabriel areas. During the early Berriasian, pronounced rif ing linked to the subsequent spreading of Iberia from the Grand Banks (Barremian-Aptian) led to regional deepening and deposition of clastic sediments (MS2) in two northeast-southwest-trending, fault-bounded subbasins in the Baccalieu and Gabriel areas. In the Aptian, Early Cretaceous subbasins were inverted due to strike-slip movement as extension assumed a northeast-southwest orientation prior to movement of Greenland/Europe away from Labrador (Albian). MS3 sediments fill northwest-southeast-trending fault-bounded depocenters typically located on areas that had formed highs during the Early Cretaceous. Postrift sedimentation continued from the Albian(?) to the present with Upper Cretaceous pelagic limestone and later clastic sediment deposition.