The Vizcaino fore-arc basin accumulated approximately 4 km (∼13,000 ft) of upper Albian–middle Eocene siliciclastic marine sedimentary rocks derived from the Peninsular Ranges in Baja California. Data from eight exploratory wells document the micropaleontological content and lithological characteristics of these rocks. The strata studied represent mostly neritic–upper bathyal marine environments and overlie a basement composed of Cretaceous granitic rocks, or Aptian–Albian volcaniclastic sedimentary rocks correlative with the Alisitos Formation. We recognize four major depositional sequences within the basin that are related to the regional geology. The basal Albian–Turonian sequence 1 represents the initiation of fore-arc basin sedimentation, contains continental conglomerates that change to bathyal shales, and correlates with the lower part of the Valle Group of the Vizcaino Peninsula. Sequence 2 is Coniacian–Paleocene, includes basal conglomeratic sandstones grading into Maastrichtian bathyal shales, and usually overlies a Coniacian–Santonian unconformity. Sequence 2 is represented at the surface by the Rosario Group in northwestern Baja California and the upper part of the Valle Group in the Vizcaino Peninsula. Sequence 3 is Paleocene–middle Eocene, represents continuity of fore-arc sedimentation in neritic–upper bathyal conditions, is capped by a major unconformity, and correlates with the Sepultura and Bateque Formations to the north and south of the basin, respectively. The uppermost Miocene–Pliocene sequence 4 is composed of marine sandstone–siltstone unconformably overlying sequence 3 and is correlative with the Tortugas Formation that represents sedimentation after the end of subduction of the Farallon plate beneath the North America plate.