Since the paper by Finch in 1824, which initiated the study of the Cretaceous and Tertiary stratigraphy of the Eastern Gulf Region, more than 200 papers dealing with the microfossils of Mississippi, Tennessee, Alabama, Georgia, Florida, and South Carolina have appeared. Of these at least 160 deal primarily with Foraminifera, 21 with Ostracoda, 11 with Bryozoa, and 4 with otoliths. In these papers nearly 700 species of Foraminifera, 150 species of Ostracoda, 580 species of Bryozoa and 23 species of otoliths have been described as new in these states. Hundreds of other species whose type localities lie in other states or countries have been reported. The formations whose type localities have been reasonably thoroughly studied for their microfaunal content are indicated. Som suggestions of needed studies are made. The paper is accompanied by an annotated bibliography which lists the species which have been described as new in this region.